MIND-AD Identifying effective prevention strategies for AD/dementia

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The anticipated pandemic increase in the number of Alzheimer disease (AD) and dementia cases carries serious implications for society. The goal of the MIND-AD project is to identify effective prevention strategies for AD/dementia tailored to different “at-risk” groups.

The project is based on experiences and data from five ongoing European intervention studies on AD/dementia prevention, including FINGER (Finland), MAPT (France), PreDIVA (Netherlands), LiPIDiDiet (Germany, Finland, Netherlands, Sweden) and HATICE (Finland, France, Netherlands, Sweden) studies. All these trials are testing the effects of multimodal interventions targeting vascular, dietary, and lifestyle-related risk factors in non-demented older adults.

The novel approach of this project consists of multi-domain interventions, inclusion of novel models of delivery (e.g. computer-based cognitive training, medical food), critical feedback from trial participants, and synergistic use of data from several European countries with over 10,000 participants.

Furthermore, a pilot study will be conducted in which a multimodal preventive intervention will be tested for the first time in prodromal AD (i.e. individuals whose memory has declined more than can be explained by ageing alone).

Consortium

Sweden

Karolinska Institute (KI) (Coordinating Center)

Professor Miia Kivipelto, MD, PhD (Project Coordinator)

Dr. Shireen Sindi, PhD

Dr. Francesca Mangialasche, MD, PhD

Professor Laura Fratiglioni, MD, PhD

Professor Lars-Olof Wahlund

Professor Anders Wimo, MD, PhD

Professor Bengt Winblad, MD, PhD

Finland

University of Eastern Finland (UEF)

Professor Hilkka Soininen, MD, PhD

Adjunct Professor Alina Solomon, MD, PhD

Dr. Tiia Ngandu, MD, PhD

France

Inserm-University of Toulouse (INSERM)

Professor Sandrine Andrieu, MD, PhD

Dr. Nicola Coley, PhD

Professor Bruno Vellas, MD, PhD

Netherlands

University of Amsterdam (AMC)

Dr. Edo Richard, MD, PhD

Professor Willem A. van Gool, MD, PhD

Germany

Saarland University (USAAR)

Professor Tobias Hartmann, PhD

United Kingdom

University of Cambridge

Professor Carol Brayne, MD, PhD

Italy

University of Perugia

Professor Patrizia Mecocci, MD, PhD

Other Collaborators

Other

Professor Martin Knapp, PhD, London School of Economics and Political Science (LSE), UK

Adjunct Professor Jyrki Lötjönen, PhD, VTT Technical Research Centre of Finland, FINLAND

Dr. Laus Broersen, Nutricia/Danone Research, Centre for Specialised Nutrition, NETHERLANDS

Jean Georges. Executive Director of Alzheimer Europe

Marc Wortmann. Executive Director of Alzheimer Disease International (ADI)

Work Plan

The project involves seven work packages (WPs)

WP1 Coordination and management

WP2 Effects, mechanisms and mediating pathways of multimodal preventive interventions

WP3 Facilitators and barriers to participation in adherence to preventive interventions

WP4 Patients with prodromal AD as target group in prevention trials

WP5 MIND-AD pilot trial, multimodal intervention in memory clinic patients

WP6 Guidelines and recommendations for AD/dementia prevention

WP7 Results dissemination and planning future larger pan-European prevention trials

Executive Management Board

Miia Kivipelto, Hilkka Soininen, Sandrine Andrieu, Tobias Hartmann, Edo Richard, Alina Solomon, Shireen Sindi.

Scientific and Clinical Coordinators

Adjunct Professor Dr. Alina Solomon and Dr. Shireen Sindi.

Financial/administrative management

The Project Support Unit located at the Center for Alzheimer Research (CAR) at KI.

News

MIND-AD Kick Off Crew

MIND-AD Kick-Off Meeting

Partners within the MIND-AD consortium met for the official Kick-Off Meeting of the project, 23rd January 2015 at the Aging Research Center in Stockholm, Sweden. Partners discussed the practical aspects of their respective tasks, as well as future plans for the collaborative initiatives.

 

MIND-AD GA Meeting in Cambridge

Sanna iPhone 160118 218

On December 15, 2015, the MIND-AD General Assembly meeting was held at the Cambridge Biomedical Campus.

Articles

FINGER published in The Lancet March 12, 2015

On March 12, 2015 “A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline

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