The anticipated pandemic increase in the number of Alzheimer disease (AD) and dementia cases carries serious implications for society. The goal of the MIND-AD project is to identify effective prevention strategies for AD/dementia tailored to different “at-risk” groups.
The project is based on experiences and data from five ongoing European intervention studies on AD/dementia prevention, including FINGER (Finland), MAPT (France), PreDIVA (Netherlands), LiPIDiDiet (Germany, Finland, Netherlands, Sweden) and HATICE (Finland, France, Netherlands, Sweden) studies. All these trials are testing the effects of multimodal interventions targeting vascular, dietary, and lifestyle-related risk factors in non-demented older adults.
The novel approach of this project consists of multi-domain interventions, inclusion of novel models of delivery (e.g. computer-based cognitive training, medical food), critical feedback from trial participants, and synergistic use of data from several European countries with over 10,000 participants.
Furthermore, a pilot study will be conducted in which a multimodal preventive intervention will be tested for the first time in prodromal AD (i.e. individuals whose memory has declined more than can be explained by ageing alone).
Professor Miia Kivipelto, MD, PhD (Project Coordinator)
Dr. Shireen Sindi, PhD
Dr. Francesca Mangialasche, MD, PhD
Professor Laura Fratiglioni, MD, PhD
Professor Lars-Olof Wahlund
Professor Anders Wimo, MD, PhD
Professor Bengt Winblad, MD, PhD
Professor Hilkka Soininen, MD, PhD
Adjunct Professor Alina Solomon, MD, PhD
Dr. Tiia Ngandu, MD, PhD
Professor Sandrine Andrieu, MD, PhD
Dr. Nicola Coley, PhD
Professor Bruno Vellas, MD, PhD
Dr. Edo Richard, MD, PhD
Professor Willem A. van Gool, MD, PhD
Professor Tobias Hartmann, PhD
Professor Carol Brayne, MD, PhD
Professor Patrizia Mecocci, MD, PhD
Professor Martin Knapp, PhD, London School of Economics and Political Science (LSE), UK
Adjunct Professor Jyrki Lötjönen, PhD, VTT Technical Research Centre of Finland, FINLAND
Dr. Laus Broersen, Nutricia/Danone Research, Centre for Specialised Nutrition, NETHERLANDS
Jean Georges. Executive Director of Alzheimer Europe
Marc Wortmann. Executive Director of Alzheimer Disease International (ADI)
WP1 Coordination and management
WP2 Effects, mechanisms and mediating pathways of multimodal preventive interventions
WP3 Facilitators and barriers to participation in adherence to preventive interventions
WP4 Patients with prodromal AD as target group in prevention trials
WP5 MIND-AD pilot trial, multimodal intervention in memory clinic patients
WP6 Guidelines and recommendations for AD/dementia prevention
WP7 Results dissemination and planning future larger pan-European prevention trials
Miia Kivipelto, Hilkka Soininen, Sandrine Andrieu, Tobias Hartmann, Edo Richard, Alina Solomon, Shireen Sindi.
Adjunct Professor Dr. Alina Solomon and Dr. Shireen Sindi.
The Project Support Unit located at the Center for Alzheimer Research (CAR) at KI.
Partners within the MIND-AD consortium met for the official Kick-Off Meeting of the project, 23rd January 2015 at the Aging Research Center in Stockholm, Sweden. Partners discussed the practical aspects of their respective tasks, as well as future plans for the collaborative initiatives.
On March 12, 2015 “A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline